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Dadun > Depósito Académico > CIMA (Centro de Investigación Médica Aplicada) > Área de Terapia génica y Hepatología > Hepatología bioquímica > DA - CIMA - Terapia génica y Hepatología - Hepatología bioquímica - Artículos de revista >

Amphiregulin: an early trigger of liver regeneration in mice
Authors: Berasain, C. (Carmen)
Garcia-Trevijano, E.R. (Elena R.)
Castillo, J. (Josefa)
Erroba, E. (Elena)
Lee, D.C. (David C.)
Prieto, J. (Jesús)
Avila, M.A. (Matías Antonio)
Keywords: Gene Expression Regulation/physiology
Glycoproteins/genetics
Intercellular Signaling Peptides and Proteins/genetics
Liver Regeneration/genetics
Issue Date: 2005
Publisher: Elsevier
Publisher version: http://www.sciencedirect.com/science/article/pii/S0016508504020025
ISSN: 1528-0012
Citation: Berasain C, Garcia-Trevijano ER, Castillo J, Erroba E, Lee DC, Prieto J, et al. Amphiregulin: an early trigger of liver regeneration in mice. Gastroenterology 2005 Feb;128(2):424-432.
Abstract
BACKGROUND AND AIMS: Liver regeneration is a unique response directed to restore liver mass after resection or injury. The survival and proliferative signals triggered during this process are conveyed by a complex network of cytokines and growth factors acting in an orderly manner. Activation of the epidermal growth factor receptor is thought to play an important role in liver regeneration. Amphiregulin is a member of the epidermal growth factor family whose expression is not detectable in healthy liver. We have investigated the expression of amphiregulin in liver injury and its role during liver regeneration after partial hepatectomy. METHODS: Amphiregulin gene expression was examined in healthy and cirrhotic human and rat liver, in rodent liver regeneration after partial hepatectomy, and in primary hepatocytes. The proliferative effects and intracellular signaling of amphiregulin were studied in isolated hepatocytes. The in vivo role of amphiregulin in liver regeneration after partial hepatectomy was analyzed in amphiregulin-null mice. RESULTS: Amphiregulin gene expression is detected in chronically injured human and rat liver and is rapidly induced after partial hepatectomy in rodents. Amphiregulin expression is induced in isolated hepatocytes by interleukin 1beta and prostaglandin E(2), but not by hepatocyte growth factor, interleukin 6, or tumor necrosis factor alpha. We show that amphiregulin behaves as a primary mitogen for isolated hepatocytes, acting through the epidermal growth factor receptor. Finally, amphiregulin-null mice display impaired proliferative responses after partial liver resection. CONCLUSIONS: Our findings indicate that amphiregulin is an early-response growth factor that may contribute to the initial phases of liver regeneration.
Permanent link: http://hdl.handle.net/10171/23254
Appears in Collections:DA - CIMA - Terapia génica y Hepatología - Hepatología bioquímica - Artículos de revista

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