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Dadun > Depósito Académico > CIMA (Centro de Investigación Médica Aplicada) > Área de Terapia génica y Hepatología > Hepatología experimental > DA - CIMA - Terapia génica y Hepatología - Hepatología experimental - Artículos de revista >

Renal prostacyclin influences renal function in non-azotemic cirrhotic patients treated with furosemide
Authors: Quiroga, J. (Jorge)
Zozaya, J.M. (José Manuel)
Labarga, P. (Pablo)
Rodriguez-Ortigosa, C.M. (Carlos M.)
Milazzo, A. (Alfredo)
Prieto, J. (Jesús)
Keywords: Epoprostenol/physiology
Furosemide/therapeutic use
Kidney/physiopathology
Liver Cirrhosis/drug therapy
Issue Date: 1991
Publisher: Elsevier
ISSN: 1600-0641
Citation: Quiroga J, Zozaya JM, Labarga P, Rodriguez-Ortigosa CM, Milazzo A, Prieto J. Renal prostacyclin influences renal function in non-azotemic cirrhotic patients treated with furosemide. J Hepatol 1991 Mar;12(2):170-175.
Abstract
The influence of prostaglandins on renal function changes induced by furosemide was analyzed in 21 non-azotemic cirrhotic patients with ascites. Patients were studied in two periods of 120 min immediately before and after furosemide infusion (20 mg, ev). Furosemide caused an increase in creatinine clearance in 15 patients (group A: 99 +/- 7 vs. 129 +/- 5 ml/min; mean +/- S.E.) and a reduction in the remaining six (group B: 102 +/- 13 vs. 71 +/- 9 ml/min). Parallel changes were observed in the urinary excretion of 6-Keto-prostaglandin-F1 alpha (metabolite of renal prostacyclin) which augmented after furosemide in 14 of the 15 patients from group A (478 +/- 107 vs. 1034 +/- 159 pg/min, p less than 0.001) and decreased in all patients from group B (1032 +/- 240 vs. 548 +/- 136 pg/min, p less than 0.05). In contrast, the urinary excretion of prostaglandin E2 was stimulated by furosemide in all patients (group A, 92 +/- 19 vs. 448 +/- 60 pg/min, p less than 0.001; and group B, 209 +/- 63 vs. 361 +/- 25 pg/min, p less than 0.05). In all of the patients furosemide-induced changes (post- minus pre-furosemide values) in creatinine clearance were closely correlated in a direct and linear fashion with those in 6-Keto-prostaglandin-F1 alpha (r = 0.74; p less than 0.001). These changes were associated with a higher furosemide-induced natriuresis in group A than in group B (641 +/- 68 vs. 302 +/-- 46 mumol/min, p less than 0.001.
Permanent link: http://hdl.handle.net/10171/23287
Appears in Collections:DA - CUN - Medicina interna - Artículos de revista
DA - CIMA - Terapia génica y Hepatología - Hepatología experimental - Artículos de revista

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