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Dadun > Depósito Académico > CIMA (Centro de Investigación Médica Aplicada) > Área de Terapia génica y Hepatología > Inmunología clínica > DA - CIMA - Terapia génica y Hepatología - Inmunología clínica - Artículos de revista >

Antioxidant status and glutathione metabolism in peripheral blood mononuclear cells from patients with chronic hepatitis C
Authors: Boya, P. (Patricia)
Peña, A. (Andrés) de la
Beloqui, O. (Óscar)
Larrea, E. (Esther)
Conchillo, M. (M.)
Castelruiz, Y. (Yurdana)
Civeira, M.P. (María Pilar)
Prieto, J. (Jesús)
Keywords: Antioxidant enzymes
Glutathione
Hepatitis C virus
Malondialdehyde
Oxidative stress
Issue Date: 1999
Publisher: Elsevier
Publisher version: http://www.sciencedirect.com/science/article/pii/S0168827899802815
ISSN: 1600-0641
Citation: Boya P, de la Pena A, Beloqui O, Larrea E, Conchillo M, Castelruiz Y, et al. Antioxidant status and glutathione metabolism in peripheral blood mononuclear cells from patients with chronic hepatitis C. J Hepatol 1999 Nov;31(5):808-814.
Abstract
BACKGROUND/AIMS: Oxidative stress could play a role in the pathogenesis of hepatitis C virus infection. We investigated the oxidant/antioxidant status in peripheral blood mononuclear cells from patients with chronic hepatitis C and controls. METHODS/RESULTS: Lipid peroxidation products and superoxide dismutase activity in peripheral blood mononuclear cells were higher in chronic hepatitis C patients than in healthy subjects while glutathione S-transferase activity was reduced in patients as compared to controls. Catalase, glutathione peroxidase and glutathione reductase were similar in chronic hepatitis C and normal individuals. No statistically significant differences were found between patients and controls with regard to glutathione levels in peripheral blood mononuclear cells, but 35% of patients with chronic hepatitis C showed values of glutathione and oxidized glutathione which were below and above, respectively, the limits of normal controls. Finally, the glutathione synthetic capacity of the cytosol of peripheral blood mononuclear cells was significantly higher in patients than in controls, indicating increased glutathione turnover in lymphocytes from patients with chronic hepatitis C. CONCLUSIONS: Oxidative stress is observed in peripheral blood mononuclear cells from chronic hepatitis C patients. This process might alter lymphocyte function and facilitate the chronicity of the infection.
Permanent link: http://hdl.handle.net/10171/23295
Appears in Collections:DA - CUN - Hepatología - Artículos de revista
DA - CUN - Medicina interna - Artículos de revista
DA - CIMA - Terapia génica y Hepatología - Inmunología clínica - Artículos de revista

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