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The adipocyte: a model for integration of endocrine and metabolic signaling in energy metabolism regulation
Authors: Frühbeck, G. (Gema)
Gomez-Ambrosi, J. (Javier)
Muruzabal, F.J. (Francisco José)
Burrell, M.A. (M.A.)
Keywords: Endocrine Glands/physiology
Energy Metabolism/physiology
Insulin Resistance/physiology
Issue Date: 2001
Publisher: American Physiological Society
Publisher version: http://ajpendo.physiology.org/content/280/6/E827.full.pdf+html
ISSN: 0193-1849
Citation: Fruhbeck G, Gomez-Ambrosi J, Muruzabal FJ, Burrell MA. The adipocyte: a model for integration of endocrine and metabolic signaling in energy metabolism regulation. Am J Physiol Endocrinol Metab 2001 Jun;280(6):E827-47.
Abstract
The ability to ensure continuous availability of energy despite highly variable supplies in the environment is a major determinant of the survival of all species. In higher organisms, including mammals, the capacity to efficiently store excess energy as triglycerides in adipocytes, from which stored energy could be rapidly released for use at other sites, was developed. To orchestrate the processes of energy storage and release, highly integrated systems operating on several physiological levels have evolved. The adipocyte is no longer considered a passive bystander, because fat cells actively secrete many members of the cytokine family, such as leptin, tumor necrosis factor-alpha, and interleukin-6, among other cytokine signals, which influence peripheral fuel storage, mobilization, and combustion, as well as energy homeostasis. The existence of a network of adipose tissue signaling pathways, arranged in a hierarchical fashion, constitutes a metabolic repertoire that enables the organism to adapt to a wide range of different metabolic challenges, such as starvation, stress, infection, and short periods of gross energy excess.
Permanent link: http://hdl.handle.net/10171/23359
Appears in Collections:DA - Medicina - Endocrinología - Artículos de revista
DA - Ciencias - HAP - Artículos de revista
DA - CUN - Endocrinología y Nutrición - Artículos de revista

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