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Dadun > Depósito Académico > Clínica Universidad de Navarra > Cirugía ortopédica y traumatología > DA - CUN - Cirugía ortopédica y traumatología - Artículos de revista >

Intraoperative radiotherapy electron boost followed by moderate doses of external beam radiotherapy in resected soft-tissue sarcoma of the extremities
Authors: Azinovic, I. (Ignacio)
Martinez-Monge, R. (Rafael)
Aristu, J. (Javier)
Salgado, E. (Esteban)
Villafranca, E. (Elena)
Fernandez-Hidalgo, O. (Óscar)
Amillo, S. (Santiago)
San-Julian, M. (Mikel)
Villas, C. (Carlos)
Aramendia, J.M. (J.M.)
Calvo, F.A. (Felipe A.)
Keywords: Intraoperative Period/adverse effects/methods
Neoplasm Recurrence, Local/radiotherapy
Peripheral Nerves/radiation effects
Issue Date: 2003
Publisher: Elsevier
Publisher version: http://ac.els-cdn.com/S0167814003001634/1-s2.0-S0167814003001634-main.pdf?_tid=f058c1ea-0fa3-11e2-9d7e-00000aab0f6b&acdnat=1349520936_94b8f5bff3a4a449c08070dd720472f8
ISSN: 0167-8140
Citation: Azinovic I, Martinez Monge R, Javier Aristu J, Salgado E, Villafranca E, Fernandez Hidalgo O, Amillo S, San Julian M, Villas C, Manuel Aramendía J, Calvo FA. Intraoperative radiotherapy electron boost followed by moderate doses of external beam radiotherapy in resected soft-tissue sarcoma of the extremities. Radiother Oncol. 2003 Jun;67(3):331-7.
Abstract
To analyze the patterns of failure and the toxicity profile of intraoperative electron beam radiotherapy (IOERT) after resection of soft tissue sarcomas of the extremities (STS). PATIENTS AND METHODS: Forty-five patients with extremity STS were treated with IOERT and moderate-dose postoperative radiotherapy (45-50 Gy). Twenty-six patients were treated for primary disease (PD) and 19 patients for an isolated recurrence (ILR). Tumor size was >5 cm (maximum diameter) in 36 patients (80%), and high-grade histology in PD patients was present in 14 patients (54%). In nine patients, IOERT was used alone, due to previous irradiation or patient refusal. Chemotherapy (neoadjuvant and/or adjuvant) was mainly given to high-grade tumors. RESULTS: Nine patients relapsed in the extremity (20%), and 12 patients in distant sites (28%). Actuarial local control at 5 years was 88% for patients with negative/close margins and 57% for patients presenting positive margins (P=0.04). Five patients (11%) developed neuropathy associated with the treatment. Extremity preservation was achieved in 40 patients (88%). With a median follow-up of 93 months (range: 27-143 months) for the patients at risk, 25 patients remain alive (a 7-year actuarial survival rate of 75% for PD and 47% for ILR; P=0.01). CONCLUSIONS: IOERT combined with moderate doses of external beam irradiation yields high local control and extremity preservation rates in resected extremity STS. Peripheral nerves in the IOERT field are dose-limiting structures requiring a dose compromise in the IOERT component to avoid severe neurological damage.
Permanent link: http://hdl.handle.net/10171/23412
Appears in Collections:DA - Medicina - Oncología - Artículos de revista
DA - CUN - Oncología radioterápica - Artículos de revista
DA - CUN - Cirugía ortopédica y traumatología - Artículos de revista

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