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http://hdl.handle.net/10171/23597
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| Title: | Synthesis and antiplasmodial activity of 3-furyl and 3-thienylquinoxaline-2-carbonitrile 1,4-di-N-oxide derivatives |
| Author(s) : | Vicente, E. (Esther)
Charnaud, S. (Sarah)
Bongard, E. (Emily)
Villar, R. (Raquel)
Burguete, A. (Asunción)
Solano, B. (Beatriz)
Ancizu, S. (Saioa)
Perez-Silanes, S. (Silvia)
Aldana, I. (Ignacio)
Vivas, L. (Livia)
Monge, A. (Antonio) |
| Issue Date: | 2008 |
| Publisher: | MDPI |
| Citation: | Vicente E, Charnaud S, Bongard E, Villar R, Burguete A, Solano B, et al. Synthesis and antiplasmodial activity of 3-furyl and 3-thienylquinoxaline-2-carbonitrile 1,4-di-N-oxide derivatives. Molecules 2008 Jan 17;13(1):69-77. |
| Keywords: | Quinoxaline
N-oxides
Malaria
Antiplasmodial
P.falciparum |
| Abstract: | The aim of this study was to identify new compounds active against
Plasmodium falciparum based on our previous research carried out on 3-phenylquinoxaline-
2-carbonitrile 1,4-di-N-oxide derivatives. Twelve compounds were
synthesized and evaluated for antimalarial activity. Eight of them showed an IC50 < 1 μM
against the 3D7 strain. Derivative 1 demonstrated high potency (IC50= 0.63 μM) and good
selectivity (SI=10.35), thereby becoming a new lead-compound. |
| URI: | http://hdl.handle.net/10171/23597 |
| Publisher version (URL): | http://www.mdpi.com/journal/molecules |
| Appears in Collections: | DA - Farmacia - Orgánica - Artículos de revista
DA - CIFA - I+D de medicamentos - Artículos de revistas
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