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Dadun > Depósito Académico > CIFA (Centro de Investigación en Farmacobiología Aplicada) > Unidad de I+D de Medicamentos > DA - CIFA - I+D de medicamentos - Artículos de revistas >

Heterocyclic-2-carboxylic acid (3-cyano-1,4-di-N-oxidequinoxalin-2-yl)amide derivatives as hits for the development of neglected disease drugs.
Authors: Ancizu, S. (Saioa)
Moreno-Viguri, E. (Elsa)
Torres, E. (Enrique)
Burguete, A. (Asunción)
Perez-Silanes, S. (Silvia)
Benitez, D. (Diego)
Villar, R. (Raquel)
Solano, B. (Beatriz)
Marin, A. (Adoración)
Aldana, I. (Ignacio)
Cerecetto, H. (Hugo)
Gonzalez, M. (Mercedes)
Monge, A. (Antonio)
Keywords: Quinoxaline
Neglected diseases
Mycobacterium tuberculosis
Trypanosoma cruz
Issue Date: 2009
Publisher: MDPI
Publisher version: http://www.mdpi.com/journal/molecules
ISSN: 1420-3049
Citation: Ancizu S, Moreno E, Torres E, Burguete A, Perez-Silanes S, Benitez D, et al. Heterocyclic-2-carboxylic acid (3-cyano-1,4-di-N-oxidequinoxalin-2-yl)amide derivatives as hits for the development of neglected disease drugs. Molecules 2009 Jun 22;14(6):2256-2272.
Abstract
Neglected diseases represent a major health problem. It is estimated that one third of the world population is infected with tuberculosis (TB). Besides TB, Chagas disease, affects approximately 20 million people. Quinoxalines display great activities against TB and Chagas. Forty new quinoxaline 1,4-di-N-oxide derivatives have been prepared and tested against M. tuberculosis and T. cruzi. Carboxylic acid quinoxaline 1,4-di-N-oxides (CAQDOs) 5 and 17 showed MIC values on the same order as the reference antituberculosis drug, rifampicin. Meanwhile, CAQDOs 12 and 22 presented IC50 values in the same order as the anti-chagasic drug, nifurtimox.
Permanent link: http://hdl.handle.net/10171/23599
Appears in Collections:DA - Farmacia - Orgánica - Artículos de revista
DA - CIFA - I+D de medicamentos - Artículos de revistas

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