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Please use this identifier to cite or link to this item:
http://hdl.handle.net/10171/23599
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| Title: | Heterocyclic-2-carboxylic acid (3-cyano-1,4-di-N-oxidequinoxalin-2-yl)amide derivatives as hits for the development of neglected disease drugs. |
| Author(s) : | Ancizu, S. (Saioa)
Moreno, E. (Elsa)
Torres, E. (Enrique)
Burguete, A. (Asunción)
Perez-Silanes, S. (Silvia)
Benitez, D. (Diego)
Villar, R. (Raquel)
Solano, B. (Beatriz)
Marin, A. (Adoración)
Aldana, I. (Ignacio)
Cerecetto, H. (Hugo)
Gonzalez, M. (Mercedes)
Monge, A. (Antonio) |
| Issue Date: | 2009 |
| Publisher: | MDPI |
| Citation: | Ancizu S, Moreno E, Torres E, Burguete A, Perez-Silanes S, Benitez D, et al. Heterocyclic-2-carboxylic acid (3-cyano-1,4-di-N-oxidequinoxalin-2-yl)amide derivatives as hits for the development of neglected disease drugs. Molecules 2009 Jun 22;14(6):2256-2272. |
| Keywords: | Quinoxaline
Neglected diseases
Mycobacterium tuberculosis
Trypanosoma cruz |
| Abstract: | Neglected diseases represent a major health problem. It is estimated that one third
of the world population is infected with tuberculosis (TB). Besides TB, Chagas disease,
affects approximately 20 million people. Quinoxalines display great activities against TB
and Chagas. Forty new quinoxaline 1,4-di-N-oxide derivatives have been prepared and
tested against M. tuberculosis and T. cruzi. Carboxylic acid quinoxaline 1,4-di-N-oxides
(CAQDOs) 5 and 17 showed MIC values on the same order as the reference antituberculosis
drug, rifampicin. Meanwhile, CAQDOs 12 and 22 presented IC50 values in the same order
as the anti-chagasic drug, nifurtimox. |
| URI: | http://hdl.handle.net/10171/23599 |
| Publisher version (URL): | http://www.mdpi.com/journal/molecules |
| Appears in Collections: | DA - Farmacia - Orgánica - Artículos de revista
DA - CIFA - I+D de medicamentos - Artículos de revistas
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