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Please use this identifier to cite or link to this item:
http://hdl.handle.net/10171/23742
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| Title: | New salicylamide and sulfonamide derivatives of quinoxaline 1,4-di-N-oxide with antileishmanial and antimalarial activities |
| Author(s) : | Barea, C. (Carlos)
Pabon, A. (Adriana)
Castillo, D. (Denis)
Zimic, M. (Mirko)
Quiliano, M. (Miguel)
Galiano, S. (Silvia)
Perez-Silanes, S. (Silvia)
Monge, A. (Antonio)
Deharo, E. (Eric)
Aldana, I. (Ignacio) |
| Issue Date: | 2011 |
| Publisher: | Elsevier |
| Citation: | Barea C, Pabon A, Castillo D, Zimic M, Quiliano M, Galiano S, et al. New salicylamide and sulfonamide derivatives of quinoxaline 1,4-di-N-oxide with antileishmanial and antimalarial activities. Bioorg Med Chem Lett 2011 Aug 1;21(15):4498-4502. |
| Keywords: | Quinoxaline
N-oxides
Malaria
Leishmaniasis |
| Abstract: | Continuing with our efforts to identify new active compounds against malaria and leishmaniasis, fourteen new 3-amino-1,4-di-N-oxide quinoxaline-2-carbonitrile derivatives were synthesized and evaluated for their in vitro antimalarial and antileishmanial activity against Plasmodium falciparum Colombian FCR-3 strain and Leishmania amazonensis strain MHOM/BR/76/LTB-012A. Further computational studies were carried out in order to analyze graphic SAR and ADME properties. The results obtained indicate that compounds with one halogenous group substituted in position 6 and 7 provide an efficient approach for further development of antimalarial and antileishmanial agents. In addition, interesting ADME properties were found |
| URI: | http://hdl.handle.net/10171/23742 |
| Publisher version (URL): | http://dx.doi.org/10.1016/j.bmcl.2011.05.125 |
| Appears in Collections: | DA - Farmacia - Orgánica - Artículos de revista
DA - CIFA - I+D de medicamentos - Artículos de revistas
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