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Dadun > Depósito Académico > CIFA (Centro de Investigación en Farmacobiología Aplicada) > Unidad de I+D de Medicamentos > DA - CIFA - I+D de medicamentos - Artículos de revistas >

New salicylamide and sulfonamide derivatives of quinoxaline 1,4-di-N-oxide with antileishmanial and antimalarial activities
Authors: Barea, C. (Carlos)
Pabon, A. (Adriana)
Castillo, D. (Denis)
Zimic, M. (Mirko)
Quiliano, M. (Miguel)
Galiano, S. (Silvia)
Perez-Silanes, S. (Silvia)
Monge, A. (Antonio)
Deharo, E. (Eric)
Aldana, I. (Ignacio)
Keywords: Quinoxaline
N-oxides
Malaria
Leishmaniasis
Issue Date: 2011
Publisher: Elsevier
Publisher version: http://dx.doi.org/10.1016/j.bmcl.2011.05.125
ISSN: 0960-894X
Citation: Barea C, Pabon A, Castillo D, Zimic M, Quiliano M, Galiano S, et al. New salicylamide and sulfonamide derivatives of quinoxaline 1,4-di-N-oxide with antileishmanial and antimalarial activities. Bioorg Med Chem Lett 2011 Aug 1;21(15):4498-4502.
Abstract
Continuing with our efforts to identify new active compounds against malaria and leishmaniasis, fourteen new 3-amino-1,4-di-N-oxide quinoxaline-2-carbonitrile derivatives were synthesized and evaluated for their in vitro antimalarial and antileishmanial activity against Plasmodium falciparum Colombian FCR-3 strain and Leishmania amazonensis strain MHOM/BR/76/LTB-012A. Further computational studies were carried out in order to analyze graphic SAR and ADME properties. The results obtained indicate that compounds with one halogenous group substituted in position 6 and 7 provide an efficient approach for further development of antimalarial and antileishmanial agents. In addition, interesting ADME properties were found
Permanent link: http://hdl.handle.net/10171/23742
Appears in Collections:DA - Farmacia - Orgánica - Artículos de revista
DA - CIFA - I+D de medicamentos - Artículos de revistas

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