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Dadun > Depósito Académico > Clínica Universidad de Navarra > Cirugía general y digestiva > DA - CUN - Cirugía general y digestiva - Artículos de revista >

Second-generation colon capsule endoscopy compared with colonoscopy
Authors: Spada, C. (Cristiano)
Muñoz-Navas, M. (Miguel)
Hassan, C. (Cesare)
Neuhaus, H. (Horst)
Deviere, J. (Jacques)
Fockens, P. (Paul)
Coron, E. (Emmanuel)
Gay, G. (Gerard)
Toth, E. (Ervin)
Riccioni, M.E. (Maria Elena)
Carretero, C. (Cristina)
Charton, J.P. (Jean P.)
Gossum, A. (Andre) van
Wientjes, C.A. (Caroline A.)
Sacher-Huvelin, S. (Sylvie)
Delvaux, M. (Michel)
Nemeth, A. (Artur)
Petruzziello, L. (Lucio)
Prieto, C. (César)
Mayershofer, R. (Rupert)
Aminejab, L. (Leila)
Dekker, E. (Evelien)
Galmiche, J.P. (Jean-Paul)
Frederic, M. (Muriel)
Johansson, G.W. (Gabriele Wurn)
Cesaro, P. (Paola)
Costamagna, G. (Guido)
Keywords: Capsule Endoscopy/adverse effects
Colonic Polyps/diagnosis/pathology
Colonoscopy/adverse effects
Issue Date: 2011
Publisher: Elsevier
Publisher version: http://dx.doi.org/10.1016/j.gie.2011.03.1125
ISSN: 0016-5107
Citation: Spada C, Hassan C, Munoz-Navas M, Neuhaus H, Deviere J, Fockens P, et al. Second-generation colon capsule endoscopy compared with colonoscopy. Gastrointest Endosc 2011 9;74(3):581-589.e1.
Abstract
Colon capsule endoscopy (CCE) represents a noninvasive technology that allows visualization of the colon without requiring sedation and air insufflation. A second-generation colon capsule endoscopy system (PillCam Colon 2) (CCE-2) was developed to increase sensitivity for colorectal polyp detection compared with the first-generation system. OBJECTIVE: To assess the feasibility, accuracy, and safety of CCE-2 in a head-to-head comparison with colonoscopy. DESIGN AND SETTING: Prospective, multicenter trial including 8 European sites. PATIENTS: This study involved 117 patients (mean age 60 years). Data from 109 patients were analyzed. INTERVENTION: CCE-2 was prospectively compared with conventional colonoscopy as the criterion standard for the detection of colorectal polyps that are >/=6 mm or masses in a cohort of patients at average or increased risk of colorectal neoplasia. Colonoscopy was independently performed within 10 hours after capsule ingestion or on the next day. MAIN OUTCOME MEASUREMENTS: CCE-2 sensitivity and specificity for detecting patients with polyps >/=6 mm and >/=10 mm were assessed. Capsule-positive but colonoscopy-negative cases were counted as false positive. Capsule excretion rate, level of bowel preparation, and rate of adverse events also were assessed. RESULTS: Per-patient CCE-2 sensitivity for polyps >/=6 mm and >/=10 mm was 84% and 88%, with specificities of 64% and 95%, respectively. All 3 invasive carcinomas were detected by CCE-2. The capsule excretion rate was 88% within 10 hours. Overall colon cleanliness for CCE-2 was adequate in 81% of patients. LIMITATIONS: Not unblinding the CCE-2 results at colonoscopy; heterogenous patient population; nonconsecutive patients. CONCLUSION: In this European, multicenter study, CCE-2 appeared to have a high sensitivity for the detection of clinically relevant polypoid lesions, and it might be considered an adequate tool for colorectal imaging.
Permanent link: http://hdl.handle.net/10171/23744
Appears in Collections:DA - CUN - Cirugía general y digestiva - Artículos de revista

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