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Please use this identifier to cite or link to this item:
http://hdl.handle.net/10171/23774
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| Title: | Emergence of Secondary Acute Leukemia in a Patient Treated for Osteosarcoma: Implications of Germline TP53 Mutations |
| Author(s) : | Panizo, C. (Carlos)
Patiño, A. (Ana)
Calasanz, M.J. (María José)
Rifon, J. (José)
Sierrasesumaga, L. (Luis)
Rocha, E. (Eduardo) |
| Issue Date: | 1998 |
| Publisher: | Wiley-Blackwell |
| Citation: | Panizo C, Patiño A, Calasanz MJ, Rifón J, Sierrasesumaga L, Rocha E. Emergence of Secondary Acute Leukemia in a Patient Treated for Osteosarcoma: Implications of Germline TP53 Mutations. Med Pediatr Oncol. 1998 Mar;30(3):165-9. |
| Keywords: | Femoral Neoplasms/drug therapy/radiotherapy/surgery
Genes, Tumor Suppressor/drug effects/genetics
Leukemia, Myeloid, Acute/chemically induced/genetics |
| Abstract: | Secondary leukemia and myelodysplastic syndromes have been reported
in patients following treatment for a wide range of neoplastic disorders. However
second malignancies after chemotherapy and/or irradiation for osteosarcoma are
unusual. PROCEDURE: We report the case of a 15-year-old girl who developed a
myelodysplastic syndrome with evolution to acute nonlymphocytic leukemia after
treatment for osteosarcoma. Therapy-related acute leukemia karyotype findings
such as abnormalities of chromosomes 5, 7, and 17 were found in the cytogenetic
analysis. Moreover, using denaturing gradient gel electrophoresis and DNA
sequencing, we detected the presence of a double germline mutation in exon 7 of
the TP53 gene. CONCLUSION: This observation supports the possibility of a causal
relationship between germline TP53 mutations and the development of secondary
leukemia and myelodysplasia |
| URI: | http://hdl.handle.net/10171/23774 |
| Publisher version (URL): | http://onlinelibrary.wiley.com/doi/10.1002/(SICI)1096-911X(199803)30:3%3C165::AID-MPO7%3E3.0.CO;2-F/pdf |
| Appears in Collections: | DA - CUN - Unidad de Genética clínica - Artículos de revista
DA - CUN - Hematología y Hemoterapia - Artículos de revista
DA - CUN - Pediatría - Artículos de revista
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