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Dadun > Depósito Académico > Clínica Universidad de Navarra > Dermatología médico-quirúrgica y venereológica > DA - CUN - Dermatología médico-quirúrgica y venereológica - Artículos de revista >

Pemphigus vulgaris autoantibodies induce apoptosis in HaCaT keratinocytes
Authors: Pelacho, B. (Beatriz)
Natal, C. (Cristina)
España, A. (Agustín)
Sanchez-Carpintero-Abad, I. (Ignacio)
Iraburu, M.J. (María J.)
Lopez-Zabalza, M.J. (María Jesús)
Keywords: Autoantibodies/immunology/pharmacology
Cytoplasm/metabolism
Keratinocytes/cytology/immunology/metabolism/ultrastructure
Issue Date: 2004
Publisher: Elsevier
Publisher version: http://dx.doi.org/10.1016/j.febslet.2004.03.107
ISSN: 0014-5793,
Citation: Pelacho B, Natal C, España A, Sánchez-Carpintero I, Iraburu MJ, López-Zabalza MJ. Pemphigus vulgaris autoantibodies induce apoptosis in HaCaT keratinocytes. FEBS Lett. 2004 May 21;566(1-3):6-10.
Abstract
Pemphigus vulgaris (PV) is an autoimmune disease characterized by binding of IgG autoantibodies to epidermal keratinocyte desmosomes. IgG autoantibodies obtained from a patient with mucocutaneous PV reacted with plakoglobin (Plkg) in addition to desmoglein-3 (Dsg3) and Dsg1. Immunofluorescence analysis confirmed that IgG autoantibodies, unlike antibodies from a healthy volunteer, caused disruption of cell-cell contacts in HaCaT keratinocytes. Moreover, apoptosis was enhanced in cells treated with autoantibodies compared to those treated with normal antibodies. The apoptotic process induced by IgG autoantibodies was characterized by caspase-3 activation, Bcl-2 depletion and Bax expression. The present report demonstrates that PV IgG autoantibodies promote apoptosis in HaCaT keratinocytes.
Permanent link: http://hdl.handle.net/10171/27358
Appears in Collections:DA - Ciencias - Bioquímica y Biología molecular - Artículos de Revista
DA - CUN - Dermatología médico-quirúrgica y venereológica - Artículos de revista

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