Full metadata record
DC Field | Value | Language |
---|---|---|
dc.creator | Aranguren, X.L. (Xabier L.) | |
dc.creator | McCue, J.D. (Jonathan D.) | |
dc.creator | Hendrickx, B. (B.) | |
dc.creator | Zhu, X.H. (Xiao Hong) | |
dc.creator | Du, F. (F.) | |
dc.creator | Chen, E. (E.) | |
dc.creator | Pelacho, B. (Beatriz) | |
dc.creator | Peñuelas-Sanchez, I. (Ivan) | |
dc.creator | Abizanda-Sarasa, G. (Gloria) | |
dc.creator | Uriz, M. (Maialen) | |
dc.creator | Frommer, S.A. (S. A.) | |
dc.creator | Ross, J.J. (John J.) | |
dc.creator | Schroeder, B.A. (Betsy A.) | |
dc.creator | Seaborn, M.S. (Meredith S.) | |
dc.creator | Adney, J. (Josuah R.) | |
dc.creator | Hagenbrock, J. (J.) | |
dc.creator | Harris, N.H. (N. H.) | |
dc.creator | Zhang, Y. (Yi) | |
dc.creator | Zhang, X. (Xiaoliang) | |
dc.creator | Nelson-Holte, M. (Molly) | |
dc.creator | Jiang, Y. (Y.) | |
dc.creator | Billiau, A.D. (A.D.) | |
dc.creator | Chen, W. (W.) | |
dc.creator | Prosper-Cardoso, F. (Felipe) | |
dc.creator | Verfaillie, C.M. (Catherine M.) | |
dc.creator | Luttun, A. (Aernout) | |
dc.date.accessioned | 2011-04-20T14:11:12Z | - |
dc.date.available | 2011-04-20T14:11:12Z | - |
dc.date.issued | 2008 | - |
dc.identifier.citation | Aranguren, X. L., McCue, J. D., Hendrickx, B., Zhu, X.-H. et al. J Clin Invest. 2008; 118(2): 505–514 | es_ES |
dc.identifier.issn | 0021-9738 | - |
dc.identifier.uri | https://hdl.handle.net/10171/17833 | - |
dc.description.abstract | Despite progress in cardiovascular research, a cure for peripheral vascular disease has not been found. We compared the vascularization and tissue regeneration potential of murine and human undifferentiated multipotent adult progenitor cells (mMAPC-U and hMAPC-U), murine MAPC-derived vascular progenitors (mMAPC-VP), and unselected murine BM cells (mBMCs) in mice with moderate limb ischemia, reminiscent of intermittent claudication in human patients. mMAPC-U durably restored blood flow and muscle function and stimulated muscle regeneration, by direct and trophic contribution to vascular and skeletal muscle growth. This was in contrast to mBMCs and mMAPC-VP, which did not affect muscle regeneration and provided only limited and transient improvement. Moreover, mBMCs participated in a sustained inflammatory response in the lower limb, associated with progressive deterioration in muscle function. Importantly, mMAPC-U and hMAPC-U also remedied vascular and muscular deficiency in severe limb ischemia, representative of critical limb ischemia in humans. Thus, unlike BMCs or vascular-committed progenitors, undifferentiated multipotent adult progenitor cells offer the potential to durably repair ischemic damage in peripheral vascular disease patients. | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | American Society for Clinical Investigation | es_ES |
dc.rights | info:eu-repo/semantics/openAccess | es_ES |
dc.subject | Materias Investigacion::Ciencias de la Salud::Oncología | es_ES |
dc.title | Multipotent adult progenitor cells sustain function of ischemic limbs in mice | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.relation.publisherversion | http://www.jci.org | es_ES |
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