Full metadata record
DC Field | Value | Language |
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dc.creator | Majano, P.L. (Pedro Lorenzo) | - |
dc.creator | Garcia-Monzon, C. (Carmelo) | - |
dc.creator | Ruiz Garcia-Trevijano, E. (Elena) | - |
dc.creator | Corrales, F.J. (Fernando José) | - |
dc.creator | Camara, J. (Javier) | - |
dc.creator | Ortiz, P. (Pablo) | - |
dc.creator | Mato, J.M. (José María) | - |
dc.creator | Avila, M.A. (Matías Antonio) | - |
dc.creator | Moreno-Otero, R. (Ricardo) | - |
dc.date.accessioned | 2012-04-02T07:49:41Z | - |
dc.date.available | 2012-04-02T07:49:41Z | - |
dc.date.issued | 2001 | - |
dc.identifier.citation | Majano PL, Garcia-Monzon C, Garcia-Trevijano ER, Corrales FJ, Camara J, Ortiz P, et al. S-Adenosylmethionine modulates inducible nitric oxide synthase gene expression in rat liver and isolated hepatocytes. J Hepatol 2001 Dec;35(6):692-699. | es_ES |
dc.identifier.issn | 1600-0641 | - |
dc.identifier.uri | https://hdl.handle.net/10171/21477 | - |
dc.description.abstract | Background/Aims: Hepatocellular availability of S-adenosylmethionine, the principal biological methyl donor, is compromised in situations of liver damage. S-Adenosylmethionine administration alleviates experimental liver injury and increases survival in cirrhotic patients. The mechanisms behind these beneficial effects of S-adenosylmethionine are not completely known. An inflammatory component is common to many of the pathological conditions in which S-adenosylmethionine grants protection to the liver. This notion led us to study the effect of S-adenosylmethionine administration on hepatic nitric oxide synthase-2 induction in response to bacterial lipopolysaccharide and proinflammatory cytokines. Methods: The effect of S-adenosylmethionine on nitric oxide synthase-2 expression was assessed in rats challenged with bacterial lipopolysaccharide and in isolated rat hepatocytes treated with proinflammatory cytokines. Interactions between S-adenosylmethionine and cytokines on nuclear factor kappa B activation and nitric oxide synthase-2 promoter transactivation were studied in isolated rat hepatocytes and HepG2 cells, respectively. Results: S-Adenosylmethionine attenuated the induction of nitric oxide synthase-2 in the liver of lipopolysaccharide-treated rats and in cytokine-treated hepatocytes. S-Adenosylmethionine accelerated the resynthesis of inhibitor kappa B alpha, blunted the activation of nuclear factor kappa B and reduced the transactivation of nitric oxide synthase-2 promoter. Conclusions: Our findings indicate that the hepatoprotective actions of S-adenosylmethionine may be mediated in part through the modulation of nitric oxide production | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | Elsevier | es_ES |
dc.rights | info:eu-repo/semantics/closedAccess | - |
dc.subject | S-Adenosylmethionine | es_ES |
dc.subject | Inducible nitric oxide synthase | es_ES |
dc.subject | Endotoxemia | es_ES |
dc.subject | Cytokines | es_ES |
dc.subject | Liver | es_ES |
dc.subject | Gene expression | es_ES |
dc.title | S-Adenosylmethionine modulates inducible nitric oxide synthase gene expression in rat liver and isolated hepatocytes | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.relation.publisherversion | http://www.sciencedirect.com/science/article/pii/S0168827801002082 | es_ES |
dc.type.driver | info:eu-repo/semantics/article | es_ES |
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