Full metadata record
DC Field | Value | Language |
---|---|---|
dc.creator | Zarate, R. (Ruth) | - |
dc.creator | Arias, F. (F.) | - |
dc.creator | Bandres, E. (Eva) | - |
dc.creator | Cubedo, E. (Elena) | - |
dc.creator | Raquel | - |
dc.creator | Garcia-Foncillas, J. (Jesús) | - |
dc.date.accessioned | 2012-06-29T08:15:44Z | - |
dc.date.available | 2012-06-29T08:15:44Z | - |
dc.date.issued | 2006 | - |
dc.identifier.citation | Zarate RN, Arias F, Bandres E, Cubedo E, Malumbres R, Garcia-Foncillas J. Xeroderma pigmentosum group D 751 polymorphism as a predictive factor in resected gastric cancer treated with chemo-radiotherapy. World J Gastroenterol 2006 Oct 7;12(37):6032-6036. | es_ES |
dc.identifier.issn | 1007-9327 | - |
dc.identifier.uri | https://hdl.handle.net/10171/22732 | - |
dc.description.abstract | AIM: To evaluate the potential association of xeroderma pigmentosum group D (XPD) codon 751 variant with outcome after chemo-radiotherapy in patients with resected gastric cancer. METHODS: We used PCR-RFLP to evaluate the genetic XPD Lys751Gln polymorphisms in 44 patients with stage III (48%) and IV (20%) gastric cancer treated with surgery following radiation therapy plus 5-fluorouracil/ leucovorin based chemotherapy. RESULTS: Statistical analysis showed that 75% (12 of 16) of relapse patients showed Lys /Lys genotype more frequently (P = 0.042). The Lys polymorphism was an independent predictor of high-risk relapse-free survival from Cox analysis (HR: 3.07, 95% CI: 1.07-8.78, P = 0.036) and Kaplan-Meir test (P = 0.027, log-rank test). CONCLUSION: XPD Lys751Gln polymorphism may be an important marker in the prediction of clinical outcome to chemo-radiotherapy in resected gastric cancer patients. | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | Baishideng | es_ES |
dc.rights | info:eu-repo/semantics/openAccess | es_ES |
dc.subject | Xeroderma pigmentosum group D gene | es_ES |
dc.subject | Gastric cancer | es_ES |
dc.subject | Radiotherapy | es_ES |
dc.title | Xeroderma pigmentosum group D 751 polymorphism as a predictive factor in resected gastric cancer treated with chemo-radiotherapy | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.relation.publisherversion | http://www.wjgnet.com/1007-9327/12/6032.pdf | es_ES |
dc.type.driver | info:eu-repo/semantics/article | es_ES |
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