Full metadata record
| DC Field | Value | Language |
|---|---|---|
| dc.creator | Vicente, E. (Esther) | - |
| dc.creator | Charnaud, S. (Sarah) | - |
| dc.creator | Bongard, E. (Emily) | - |
| dc.creator | Raquel | - |
| dc.creator | Burguete, A. (Asunción) | - |
| dc.creator | Solano, B. (Beatriz) | - |
| dc.creator | Ancizu, S. (Saioa) | - |
| dc.creator | Pérez-Silanes, S. (Silvia) | - |
| dc.creator | Aldana, I. (Ignacio) | - |
| dc.creator | Vivas, L. (Livia) | - |
| dc.creator | Monge, A. (Antonio) | - |
| dc.date.accessioned | 2012-10-31T16:30:47Z | - |
| dc.date.available | 2012-10-31T16:30:47Z | - |
| dc.date.issued | 2008 | - |
| dc.identifier.citation | Vicente E, Charnaud S, Bongard E, Villar R, Burguete A, Solano B, et al. Synthesis and antiplasmodial activity of 3-furyl and 3-thienylquinoxaline-2-carbonitrile 1,4-di-N-oxide derivatives. Molecules 2008 Jan 17;13(1):69-77. | es_ES |
| dc.identifier.issn | 1420-3049 | - |
| dc.identifier.uri | https://hdl.handle.net/10171/23597 | - |
| dc.description.abstract | The aim of this study was to identify new compounds active against Plasmodium falciparum based on our previous research carried out on 3-phenylquinoxaline- 2-carbonitrile 1,4-di-N-oxide derivatives. Twelve compounds were synthesized and evaluated for antimalarial activity. Eight of them showed an IC50 < 1 μM against the 3D7 strain. Derivative 1 demonstrated high potency (IC50= 0.63 μM) and good selectivity (SI=10.35), thereby becoming a new lead-compound. | es_ES |
| dc.language.iso | eng | es_ES |
| dc.publisher | MDPI | es_ES |
| dc.rights | info:eu-repo/semantics/openAccess | es_ES |
| dc.subject | Quinoxaline | es_ES |
| dc.subject | N-oxides | es_ES |
| dc.subject | Malaria | es_ES |
| dc.subject | Antiplasmodial | es_ES |
| dc.subject | P.falciparum | es_ES |
| dc.title | Synthesis and antiplasmodial activity of 3-furyl and 3-thienylquinoxaline-2-carbonitrile 1,4-di-N-oxide derivatives | es_ES |
| dc.type | info:eu-repo/semantics/article | es_ES |
| dc.relation.publisherversion | http://www.mdpi.com/journal/molecules | es_ES |
| dc.type.driver | info:eu-repo/semantics/article | es_ES |
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