Full metadata record
DC Field | Value | Language |
---|---|---|
dc.creator | Pérez-Silanes, S. (Silvia) | - |
dc.creator | Berrade, L. (Luis) | - |
dc.creator | Garcia–Sanchez, R.N. (Rory N.) | - |
dc.creator | Mendoza, A. (Adela) | - |
dc.creator | Galiano, S. (Silvia) | - |
dc.creator | Martin-Perez-Solorzano, B. (Berta) | - |
dc.creator | Nogal-Ruiz, J.J. (Juan J.) | - |
dc.creator | Martinez-Fernandez, A.R. (Antonio R.) | - |
dc.creator | Aldana, I. (Ignacio) | - |
dc.creator | Monge, A. (Antonio) | - |
dc.date.accessioned | 2012-10-31T17:34:06Z | - |
dc.date.available | 2012-10-31T17:34:06Z | - |
dc.date.issued | 2009 | - |
dc.identifier.citation | Perez-Silanes S, Berrade L, Garcia-Sanchez RN, Mendoza A, Galiano S, Perez-Solorzano BM, et al. New 1-aryl-3-substituted propanol derivatives as antimalarial agents. Molecules 2009 Oct 14;14(10):4120-4135. | es_ES |
dc.identifier.issn | 1420-3049 | - |
dc.identifier.uri | https://hdl.handle.net/10171/23600 | - |
dc.description.abstract | This paper describes the synthesis and in vitro antimalarial activity against a P. falciparum 3D7 strain of some new 1-aryl-3-substituted propanol derivatives. Twelve of the tested compounds showed an IC50 lower than 1 μM. These compounds were also tested for cytotoxicity in murine J774 macrophages. The most active compounds were evaluated for in vivo activity against P. berghei in a 4-day suppressive test. Compound 12 inhibited more than 50% of parasite growth at a dose of 50 mg/kg/day. In addition, an FBIT test was performed to measure the ability to inhibit ferriprotoporphyrin biocrystallization. This data indicates that 1-aryl-3-substituted propanol derivatives hold promise as a new therapeutic option for the treatment of malaria. | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | MDPI | es_ES |
dc.rights | info:eu-repo/semantics/openAccess | es_ES |
dc.subject | Antimalarial agents | es_ES |
dc.subject | Benzo(b)thiophene | es_ES |
dc.subject | 1-aryl-3-substituted propanol derivatives | es_ES |
dc.subject | P. Falciparum | es_ES |
dc.subject | Ferriprotoporphyrin | es_ES |
dc.title | New 1-aryl-3-substituted propanol derivatives as antimalarial agents | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.relation.publisherversion | http://www.mdpi.com/journal/molecules | es_ES |
dc.type.driver | info:eu-repo/semantics/article | es_ES |
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