An easy and direct method for the synthesis of 1,2,4-triazole derivatives through carboxylic acids and hydrazinophthalazine

Rivera, G. (Gildardo); Bocanegra-Garcia, V. (Virgilio); Moreno-Herrera, A. (Antonio); Galiano, S. (Silvia); Pérez-Silanes, S. (Silvia); Aldana, I. (Ignacio); Monge, A. (Antonio)

Authors:

Rivera, G. (Gildardo)

Bocanegra-Garcia, V. (Virgilio)

Moreno-Herrera, A. (Antonio)

Galiano, S. (Silvia)

Pérez-Silanes, S. (Silvia)

Aldana, I. (Ignacio)

Monge, A. (Antonio)

Keywords:

1,2,4-triazoles
Carboxylic acids
Hydrazinophthalazine

Issue Date:

2008

Publisher:

Sociedade Brasileira de Química

ISSN:

0100-4042

Citation:

Rivera G, Bocanegra-Garcia V, Moreno A, Galiano S, Perez S, Aldana I, et al. An easy and direct method for the synthesis of 1,2,4-triazole derivatives through carboxylic acids and hydrazinophthalazine. Quim Nova 2008;31(3):536-538

Abstract

We have developed an easy method for the synthesis of thirteen compounds derived from 1,2,4-triazoles through a carboxylic acid and hydrazinophthalazine reaction, with a 75-85% yield mediated by the use of agents such as 1-ethyl-3-(3'-dimethylaminopropyl)-carbodiimide hydrochloride and 1-hydroxybenzotriazole. The operational simplicity of this method and the good yield of products make it valuable for the synthesis of new compounds with pharmacological activity.

URI:

https://hdl.handle.net/10171/29496

DOI:

http://dx.doi.org/10.1590/S0100-40422008000300014

Appears in Collections:

DA - CIFA - I+D de medicamentos - Artículos de revistas
DA - Farmacia - Orgánica - Artículos de revista

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