An easy and direct method for the synthesis of 1,2,4-triazole derivatives through carboxylic acids and hydrazinophthalazine

Rivera, G. (Gildardo); Bocanegra-Garcia, V. (Virgilio); Moreno-Herrera, A. (Antonio); Galiano, S. (Silvia); Pérez-Silanes, S. (Silvia); Aldana, I. (Ignacio); Monge, A. (Antonio)

Autor(es):

Rivera, G. (Gildardo)

Bocanegra-Garcia, V. (Virgilio)

Moreno-Herrera, A. (Antonio)

Galiano, S. (Silvia)

Pérez-Silanes, S. (Silvia)

Aldana, I. (Ignacio)

Monge, A. (Antonio)

Palabras clave :

1,2,4-triazoles
Carboxylic acids
Hydrazinophthalazine

Fecha de publicación :

2008

Editorial :

Sociedade Brasileira de Química

ISSN :

0100-4042

Cita:

Rivera G, Bocanegra-Garcia V, Moreno A, Galiano S, Perez S, Aldana I, et al. An easy and direct method for the synthesis of 1,2,4-triazole derivatives through carboxylic acids and hydrazinophthalazine. Quim Nova 2008;31(3):536-538

Resumen

We have developed an easy method for the synthesis of thirteen compounds derived from 1,2,4-triazoles through a carboxylic acid and hydrazinophthalazine reaction, with a 75-85% yield mediated by the use of agents such as 1-ethyl-3-(3'-dimethylaminopropyl)-carbodiimide hydrochloride and 1-hydroxybenzotriazole. The operational simplicity of this method and the good yield of products make it valuable for the synthesis of new compounds with pharmacological activity.

URI :

https://hdl.handle.net/10171/29496

DOI:

http://dx.doi.org/10.1590/S0100-40422008000300014

Aparece en las colecciones:

DA - CIFA - I+D de medicamentos - Artículos de revistas
DA - Farmacia - Orgánica - Artículos de revista

Ficheros en este ítem: