Synthesis, biological evaluation and structure-activity relationships of new quinoxaline derivatives as anti-Plasmodium falciparum agents

Aldana, I. (Ignacio); Monge, A. (Antonio); Deharo, E. (Eric); Pérez-Silanes, S. (Silvia); Burguete, A. (Asunción); Galiano, S. (Silvia); Pabon, A. (Adriana); Gil, A. (Ana)

Authors:

Aldana, I. (Ignacio)

Monge, A. (Antonio)

Deharo, E. (Eric)

Pérez-Silanes, S. (Silvia)

Burguete, A. (Asunción)

Galiano, S. (Silvia)

Pabon, A. (Adriana)

Gil, A. (Ana)

Keywords:

Chalcone
Quinoxaline 1,4-di-N-oxide
Quinoxaline
Antimalarial agents
Plasmodium falciparum

Issue Date:

18-Feb-2014

Publisher:

MDPI (Molecular Diversity Preservation International)

Project:

PIUNA Project of the University of Navarra

ISSN:

1420-3049

Citation:

Gil A, Pabón A, Galiano S, Burguete A, Pérez-Silanes S, Deharo E, et al. Synthesis, biological evaluation and structure-activity relationships of new quinoxaline derivatives as anti-Plasmodium falciparum agents. Molecules 2014 Feb 18;19(2):2166-2180

Abstract

We report the synthesis and antimalarial activities of eighteen quinoxaline and quinoxaline 1,4-di-N-oxide derivatives, eight of which are completely novel. Compounds 1a and 2a were the most active against Plasmodium falciparum strains. Structure-activity relationships demonstrated the importance of an enone moiety linked to the quinoxaline ring.

URI:

https://hdl.handle.net/10171/35725

DOI:

http://dx.doi.org/10.3390/molecules19022166

Appears in Collections:

DA - CIFA - I+D de medicamentos - Artículos de revistas
DA - Farmacia - Orgánica - Artículos de revista

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