New 3-methylquinoxaline-2-carboxamide 1,4-di-N-oxide derivatives as anti- Mycobacterium tuberculosis agents.

Monge, A. (Antonio); Aldana, I. (Ignacio); Pérez-Silanes, S. (Silvia); Torres, E. (Enrique); Burguete, A. (Asunción); Raquel; Solano, B. (Beatriz); Moreno-de-Viguri, E. (Elsa); Ancizu, S. (Saioa)

Keywords:

Rifampin
Mycobacterium tuberculosis
Quinoxaline 1,4-di-N-oxide
Anti-tuberculosis agents

Issue Date:

20-Feb-2010

Publisher:

Elsevier

Project:

RIDIMEDCHAG-CYTED and PIUNA project from University of Navarra. We also wish to express our gratitude to the Tuberculosis Antimicrobial Acquisition & Coordinating Facility (TAACF) for the evaluation of the anti-tuberculosis activity through research and development contracts. S.A.

ISSN:

0968-0896

Citation:

Ancizu S, Moreno E, Solano B, Villar R, Burguete A, Torres E, et al. New 3-methylquinoxaline-2-carboxamide 1,4-di-N-oxide derivatives as anti-Mycobacterium tuberculosis agents. Bioorg Med Chem 2010 4/1;18(7):2713-2719

Abstract

Mycobacterium tuberculosis (M.Tb) is a bacillus capable of causing a chronic and fatal condition in humans known as tuberculosis (TB). It is estimated that there are 8 million new cases of TB per year and 3.1 million infected people die annually. Thirty-six new amide quinoxaline 1,4-di-N-oxide derivatives have been synthesized and evaluated as potential anti-tubercular agents,obtaining biological values similar to the reference compound, Rifampin (RIF).

URI:

https://hdl.handle.net/10171/35790

DOI:

http://dx.doi.org/10.1016/j.bmc.2010.02.024

Appears in Collections:

DA - CIFA - I+D de medicamentos - Artículos de revistas
DA - Farmacia - Orgánica - Artículos de revista

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