Full metadata record
DC Field | Value | Language |
---|---|---|
dc.creator | Fernandez-Hidalgo, Ó. (Óscar) | - |
dc.creator | Gonzalez, F. (Fidel) | - |
dc.creator | Gil, A. (A.) | - |
dc.creator | Campbell, W. (W.) | - |
dc.creator | Barrajon, E. (E.) | - |
dc.creator | Lacave, A.J. (A. J.) | - |
dc.date.accessioned | 2014-09-04T14:44:57Z | - |
dc.date.available | 2014-09-04T14:44:57Z | - |
dc.date.issued | 1989 | - |
dc.identifier.citation | Fernández Hidalgo O, González F, Gil A, Campbell W, Barrajón E, Lacave AJ. 120 hours simultaneous infusion of cisplatin and fluorouracil in metastatic breast cancer. Am J Clin Oncol. 1989 Oct;12(5):397-401. | es_ES |
dc.identifier.issn | 0277-3732 | - |
dc.identifier.uri | https://hdl.handle.net/10171/36489 | - |
dc.description.abstract | Thirty-six patients with metastatic breast cancer, 23 with documented progression of the disease after first-line chemotherapy (CAF or CMF) and 13 without prior chemotherapy, were treated with a simultaneous 120-h infusion of cisplatin (CDDP) and 5-fluorouracil (5-FU). Objective response was demonstrated in 19 patients (52.7%), stable disease in 7 patients (19.4%) and progression of the disease in 10 patients (27.7%). Similar response rate was observed according to tumor site (soft tissues, 50%; bone, 52%; lung, 63%; liver, 55%; and pleura and peritoneum, 42%) and previous treatment (previous chemotherapy, 48%; previously untreated, 61%). Median duration of response was 8 months. Toxicity was characterized by stomatitis and myelodepression and required dose adjustments in 30% of patients. CDDP and 5-FU infusion deserve further investigation because it appeared to have substantial activity in this preliminary study in metastatic breast cancer. | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | Lippincott, Williams & Wilkins | es_ES |
dc.rights | info:eu-repo/semantics/openAccess | es_ES |
dc.subject | Breast cancer | es_ES |
dc.subject | Cisplatin | es_ES |
dc.subject | Fluorouracil | es_ES |
dc.subject | Chemotherapy | es_ES |
dc.title | 120 hours simultaneous infusion of cisplatin and fluorouracil in metastatic breast cancer | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
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