Full metadata record
DC Field | Value | Language |
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dc.creator | Ordovas, J.M. (Jose Maria) | - |
dc.creator | Ros, E. (Emilio) | - |
dc.creator | Fito, M. (Montserrat) | - |
dc.creator | Basora, J. (Josep) | - |
dc.creator | Diez-Espino, J. (Javier) | - |
dc.creator | Fiol, M. (Miquel) | - |
dc.creator | Portoles, O. (Olga) | - |
dc.creator | Gomez-Gracia, E. (Enrique) | - |
dc.creator | Serra-Majem, L. (Luis) | - |
dc.creator | Ortega-Calvo, M. (Manuel) | - |
dc.creator | Martinez-Gonzalez, M.A. (Miguel Ángel) | - |
dc.creator | Quiles, L. (Laura) | - |
dc.creator | Estruch, R. (Ramón) | - |
dc.creator | Sorli, J.V. (Jose V.) | - |
dc.creator | Coltell, O. (Oscar) | - |
dc.creator | Corella, D. (Dolores) | - |
dc.date.accessioned | 2017-05-02T09:49:18Z | - |
dc.date.available | 2017-05-02T09:49:18Z | - |
dc.date.issued | 2016 | - |
dc.identifier.citation | Corella D., Coltell O., Sorlí J. V., Estruch R., Quiles L, Martinez-Gonzalez, M. A., et al. Polymorphism of the transcription factor 7-like 2 gene (TCF7L2) interacts with obesity on type-2 diabetes in the PREDIMED study emphasizing the heterogeneity of genetic variants in type-2 diabetes risk prediction: time for obesity-specific genetic risk scores. Nutrients 2016 Dec;8(12):793. | es_ES |
dc.identifier.issn | 2072-6643 | - |
dc.identifier.uri | https://hdl.handle.net/10171/43266 | - |
dc.description.abstract | Nutrigenetic studies analyzing gene–diet interactions of the TCF7L2-rs7903146 C > T polymorphism on type-2 diabetes (T2D) have shown controversial results. A reason contributing to this may be the additional modulation by obesity. Moreover, TCF7L2-rs7903146 is one of the most influential variants in T2D-genetic risk scores (GRS). Therefore, to increase the predictive value (PV) of GRS it is necessary to first see whether the included polymorphisms have heterogeneous effects. We comprehensively investigated gene-obesity interactions between the TCF7L2-rs7903146 C > T polymorphism on T2D (prevalence and incidence) and analyzed other T2D-polymorphisms in a sub-sample. We studied 7018 PREDIMED participants at baseline and longitudinally (8.7 years maximum follow-up). Obesity significantly interacted with the TCF7L2-rs7903146 on T2D prevalence, associations being greater in non-obese subjects. Accordingly, we prospectively observed in non-T2D subjects (n = 3607) that its association with T2D incidence was stronger in non-obese (HR: 1.81; 95% CI: 1.13–2.92, p = 0.013 for TT versus CC) than in obese subjects (HR: 1.01; 95% CI: 0.61–1.66; p = 0.979; p-interaction = 0.048). Accordingly, TCF7L2-PV was higher in non-obese subjects. Additionally, we created obesity-specific GRS with ten T2D-polymorphisms and demonstrated for the first time their higher strata-specific PV. In conclusion, we provide strong evidence supporting the need for considering obesity when analyzing the TCF7L2 effects and propose the use of obesity-specific GRS for T2D. | es_ES |
dc.language.iso | spa | es_ES |
dc.publisher | MDPI | es_ES |
dc.rights | info:eu-repo/semantics/openAccess | es_ES |
dc.subject | PREDIMED study | es_ES |
dc.subject | TCF7L2-predictive value | es_ES |
dc.subject | T2D-genetic risk scores | es_ES |
dc.subject | Obesity | es_ES |
dc.subject | Type-2 diabetes | es_ES |
dc.subject | TCF7L2 | es_ES |
dc.subject | Materias Investigacion::Ciencias de la Salud::Salud pública | es_ES |
dc.title | Polymorphism of the transcription factor 7-like 2 gene (TCF7L2) interacts with obesity on type-2 diabetes in the PREDIMED study emphasizing the heterogeneity of genetic variants in type-2 diabetes risk prediction: time for obesity-specific genetic risk scores | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.description.note | Creative Commons Attribution License 4.0 | es_ES |
dc.identifier.doi | http://dx.doi.org/10.3390/nu8120793 | es_ES |
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