Characterization of biventricular alterations in myocardial (reverse) remodelling in aortic bandinginduced chronic pressure overload

Miranda-Silva, D. (Daniela); Gonçalves-Rodrigues, P. (Patrícia); Almeida-Coelho, J. (João); Hamdani, N. (Nazha); Lima, T. (Tania); Conceição, G. (Glória); Sousa-Mendes, C. (Cláudia); Moura, C. (Cláudia); Gonzalez, A. (Arantxa); Diez-Martinez, J. (Javier); Linke, W.A. (Wolfgang A.); Leite-Moreira, A. (Adelino); Falcão-Pires, I. (Ines)

Keywords:

Materias Investigacion::Ciencias de la Salud::Cardiología

Issue Date:

2019

Publisher:

Springer Science and Business Media LLC

Project:

SFRH/BD/96026/2013 - SFRH/BD/96026/2013 - Potential role of microRNAs as biomarkers and therapeutic targets during left ventricular reverse remodeling
SFRH/BD/87556/2012 - SFRH/BD/87556/2012 - THE ROLE OF TITIN ON DIASTOLIC HEART FAILURE PATHOPHYSIOLOGY: FROM THE ANIMAL MODEL TO PATIENTS AND BACK

ISSN:

2045-2322

Note:

This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made

Citation:

Miranda-Silva, D. (Daniela); Gonçalves-Rodrigues, P. (Patrícia); Almeida-Coelho, J. (João); et al. "Characterization of biventricular alterations in myocardial (reverse) remodelling in aortic bandinginduced chronic pressure overload". Scientific Reports. 9 (2956), 2019, 1 - 14

Abstract

Aortic Stenosis (AS) is the most frequent valvulopathy in the western world. Traditionally aortic valve replacement (AVR) has been recommended immediately after the onset of heart failure (HF) symptoms. However, recent evidence suggests that AVR outcome can be improved if performed earlier. After AVR, the process of left ventricle (LV) reverse remodelling (RR) is variable and frequently incomplete. In this study, we aimed at detecting mechanism underlying the process of LV RR regarding myocardial structural, functional and molecular changes before the onset of HF symptoms. Wistar-Han rats were subjected to 7-weeks of ascending aortic-banding followed by a 2-week period of debanding to resemble AS-induced LV remodelling and the early events of AVR-induced RR, respectively. This resulted in 3 groups: Sham (n = 10), Banding (Ba, n = 15) and Debanding (Deb, n = 10). Concentric hypertrophy and diastolic dysfunction (DD) were patent in the Ba group. Aortic-debanding induced RR, which promoted LV functional recovery, while cardiac structure did not normalise. Cardiac parameters of RV dysfunction, assessed by echocardiography and at the cardiomyocyte level prevailed altered after debanding. After debanding, these alterations were accompanied by persistent changes in pathways associated to myocardial hypertrophy, fibrosis and LV inflammation. Aortic banding induced pulmonary arterial wall thickness to increase and correlates negatively with effort intolerance and positively with E/e' and left atrial area. We described dysregulated pathways in LV and RV remodelling and RR after AVR. Importantly we showed important RV-side effects of aortic constriction, highlighting the impact that LV-reverse remodelling has on both ventricles.

URI:

https://hdl.handle.net/10171/62140

DOI:

10.1038/s41598-019-39581-9

Appears in Collections:

DA - CIMA - Enfermedades cardiovasculares - Remodelado miocárdico - Artículos de Revista
DA - CUN - Cirugía cardiaca - Artículos de revista

Files in This Item: