Full metadata record
DC Field | Value | Language |
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dc.creator | Lamo-Espinosa, J.M. (J. M.) | - |
dc.creator | Mora, G. (Gonzalo) | - |
dc.creator | Blanco, J.F. (J. F.) | - |
dc.creator | Granero-Moltó, F. (Froilán) | - |
dc.creator | Nuñez-Cordoba, J.M. (Jorge M.) | - |
dc.creator | López-Elío, S. (Silvia) | - |
dc.creator | Andreu, E.J. (Enrique José) | - |
dc.creator | Sanchez-Guijo, F.M. (Fermín M.) | - |
dc.creator | Aquerreta, D. (Dámaso) | - |
dc.creator | Bondia, J.M. (J. M.) | - |
dc.creator | Valentí-Azcárate, A. (Andrés) | - |
dc.creator | Cañizo, C. (C.) del | - |
dc.creator | Villarón, E. (Eva) | - |
dc.creator | Valentí-Nin, J.R. (Juan Ramón) | - |
dc.creator | Prosper-Cardoso, F. (Felipe) | - |
dc.date.accessioned | 2022-10-19T07:57:58Z | - |
dc.date.available | 2022-10-19T07:57:58Z | - |
dc.date.issued | 2018 | - |
dc.identifier.citation | Lamo-Espinosa, J.M. (J. M.); Mora, G. (Gonzalo); Blanco, J.F. (J. F.); et al. "Intra-articular injection of two different doses of autologous bone marrow mesenchymal stem cells versus hyaluronic acid in the treatment of knee osteoarthritis: long-term follow up of a multicenter randomized controlled clinical trial (phase I/II)". JOURNAL OF TRANSLATIONAL MEDICINE. 16 (1), 2018, 213 | es_ES |
dc.identifier.issn | 1479-5876 | - |
dc.identifier.uri | https://hdl.handle.net/10171/64490 | - |
dc.description.abstract | Background: Mesenchymal stromal cells (MSCs) are a promising option to treat knee osteoarthritis (OA). Their safety and usefulness have been reported in several short-term clinical trials but less information is available on the longterm efects of MSC in patients with osteoarthritis. We have evaluated patients included in our previous randomized clinical trial (CMM-ART, NCT02123368) to determine their long-term clinical efect. Materials: A phase I/II multicenter randomized clinical trial with active control was conducted between 2012 and 2014. Thirty patients diagnosed with knee OA were randomly assigned to Control group, intraarticularly administered hyaluronic acid alone, or to two treatment groups, hyaluronic acid together with 10×106 or 100×106 cultured autol‑ ogous bone marrow-derived MSCs (BM-MSCs), and followed up for 12 months. After a follow up of 4 years adverse efects and clinical evolution, assessed using VAS and WOMAC scorings are reported. Results: No adverse efects were reported after BM-MSCs administration or during the follow-up. BM-MSCs-adminis‑ tered patients improved according to VAS, median value (IQR) for Control, Low-dose and High-dose groups changed from 5 (3, 7), 7 (5, 8) and 6 (4, 8) to 7 (6, 7), 2 (2, 5) and 3 (3, 4), respectively at the end of follow up (Low-dose vs Control group, p=0.01; High-dose vs Control group, p=0.004). Patients receiving BM-MSCs also improved clinically accord‑ ing to WOMAC. Control group showed an increase median value of 4 points (−11;10) while Low-dose and Highdose groups exhibited values of −18 (−28;−9) and −10 (−21;−3) points, respectively (Low-dose vs Control group p=0.043). No clinical diferences between the BM-MSCs receiving groups were found. Conclusions: Single intraarticular injection of in vitro expanded autologous BM-MSCs is a safe and feasible proce‑ dure that results in long-term clinical and functional improvement of knee OA. | es_ES |
dc.description.sponsorship | Clinical Trial has been partially supported by grants PI17/00163 (MINECO through Instituto de Salud Carlos III to FG-M) and RD12/0019/0017 and RD12/0019/0031 from Instituto de Salud Carlos III (Red TerCel) and RD16/0011/0005 to FP. EMV is supported by Centro en Red de Medicina Regenerativa y Terapia Celular de Castilla y León, Consejería de Sanidad, Junta de Castilla y León. | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | BMC | es_ES |
dc.rights | info:eu-repo/semantics/openAccess | es_ES |
dc.subject | Knee osteoarthritis | es_ES |
dc.subject | Mesenchymal stem cells | es_ES |
dc.subject | Intraarticular injection | es_ES |
dc.title | Intra-articular injection of two different doses of autologous bone marrow mesenchymal stem cells versus hyaluronic acid in the treatment of knee osteoarthritis: long-term follow up of a multicenter randomized controlled clinical trial (phase I/II) | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.description.note | This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/ publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. | es_ES |
dc.identifier.doi | 10.1186/s12967-018-1591-7 | - |
dadun.citation.number | 1 | es_ES |
dadun.citation.publicationName | JOURNAL OF TRANSLATIONAL MEDICINE | es_ES |
dadun.citation.startingPage | 213 | es_ES |
dadun.citation.volume | 16 | es_ES |
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